Monobloc developed by Pierre Robin (surgeon) in 1902 is considered to be one of the first functional appliances in Orthodontics. The Monobloc was a modification of Ottolengui’s removable plate.
Pierre Robin syndrome (abbreviated to PRS, and also known as Pierre Robin sequence, Pierre Robin malformation, Pierre Robin anomaly or Pierre Robin anomalad) is a congenital condition of facial abnormalities in humans. PRS is a sequence, i.e. a chain of certain developmental malformations, one entailing the next. The three main features are micrognathia (abnormally small jaw or mandible) and glossoptosis resulting in airway obstruction caused by backwards displacement of the tongue base). A genetic cause to PRS was recently identified. Pierre Robin sequence may be caused by genetic anomalies at chromosomes 2, 11, or 17.